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M94A0283.TXT
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1994-10-08
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Document 0283
DOCN M94A0283
TI Evaluation of temperature sensitivity of human papillomavirus type 11 by
using the human xenograft severe combined immunodeficiency mouse model.
DT 9412
AU Bonnez W; Rose RC; Borkhuis C; Da Rin C; Reichman RC; Department of
Medicine, University of Rochester School of; Medicine and Dentistry, New
York 14642.
SO J Clin Microbiol. 1994 Jun;32(6):1575-7. Unique Identifier : AIDSLINE
MED/94358134
AB The temperature sensitivity of human papillomavirus type 11 was
evaluated by using a human xenograft severe combined immunodeficiency
mouse model. Incubation of the virus for 1 h at a temperature higher
than 56 degrees C but lower than 72 degrees C was sufficient to inhibit
the virally induced growth of infected human tissue. However, 100
degrees C was necessary to completely inactivate HPV type 11 genome
expression.
DE Animal Base Sequence Condylomata Acuminata/*MICROBIOLOGY DNA Probes,
HPV Human Male Mice *Mice, SCID Molecular Sequence Data
Papillomavirus, Human/CLASSIFICATION/*PHYSIOLOGY Penile
Neoplasms/*MICROBIOLOGY Severe Combined Immunodeficiency/MICROBIOLOGY
Skin/MICROBIOLOGY Skin Transplantation Subrenal Capsule Assay
Support, U.S. Gov't, P.H.S. *Temperature JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).